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4,320 results

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Page 1
Catalytic alkylation of unactivated C(sp(3))-H bonds for C(sp(3))-C(sp(3)) bond formation.
Chen Z , Rong MY , Nie J , Zhu XF , Shi BF , Ma JA . Chen Z , et al. Chem Soc Rev. 2019 Sep 16;48(18):4921-4942. doi: 10.1039/c9cs00086k. Chem Soc Rev. 2019. PMID: 31403147 Review.
This review summarizes the early adventures and recent advancements in catalytic transformation of unactivated C(sp3)-H bonds into C(sp3)-C(sp3) bonds. To date, three main strategies have emerged to enable this transformation, namely, metallocarbene-triggered C(sp3)-H alky …
This review summarizes the early adventures and recent advancements in catalytic transformation of unactivated C(sp3)-H bonds into C( …
Transition Metal-Catalyzed Dicarbofunctionalization of Unactivated Olefins.
Dhungana RK, Kc S, Basnet P, Giri R. Dhungana RK, et al. Chem Rec. 2018 Sep;18(9):1314-1340. doi: 10.1002/tcr.201700098. Epub 2018 Mar 8. Chem Rec. 2018. PMID: 29517841 Review.
Transition metal (TM)-catalyzed difunctionalization of unactivated olefins with two carbon-based entities is a powerful method to construct complex molecular architectures rapidly from simple and readily available feedstock chemicals. While dicarbofunctionalization of u …
Transition metal (TM)-catalyzed difunctionalization of unactivated olefins with two carbon-based entities is a powerful method to con …
Cu-catalysed transamidation of unactivated aliphatic amides.
Kumar V, Dhawan S, Bala R, Mohite SB, Singh P, Karpoormath R. Kumar V, et al. Org Biomol Chem. 2022 Aug 31;20(34):6931-6940. doi: 10.1039/d2ob01152b. Org Biomol Chem. 2022. PMID: 35983826
Direct transamidation is gaining prominence as a ground-breaking technique that generates a wide variety of amides without the requirement of acid-amine coupling or other intermediate steps. However, transamidation of unactivated aliphatic amides, on the other hand, has be …
Direct transamidation is gaining prominence as a ground-breaking technique that generates a wide variety of amides without the requirement o …
Metal-free electrochemical dihydroxylation of unactivated alkenes.
Liu M, Feng T, Wang Y, Kou G, Wang Q, Wang Q, Qiu Y. Liu M, et al. Nat Commun. 2023 Oct 13;14(1):6467. doi: 10.1038/s41467-023-42106-8. Nat Commun. 2023. PMID: 37833286 Free PMC article.
Herein, a metal-free electrochemical dihydroxylation of unactivated alkenes is described. The transformation proceeds smoothly under mild conditions with a broad range of unactivated alkenes, providing valuable and versatile dihydroxylated products in moderate to go …
Herein, a metal-free electrochemical dihydroxylation of unactivated alkenes is described. The transformation proceeds smoothly under …
Nickel-Catalyzed 1,1-Aminoborylation of Unactivated Terminal Alkenes.
Talavera L, Freund RRA, Zhang H, Wakeling M, Jensen M, Martin R. Talavera L, et al. ACS Catal. 2023 Apr 10;13(8):5538-5543. doi: 10.1021/acscatal.3c00888. eCollection 2023 Apr 21. ACS Catal. 2023. PMID: 37404837 Free PMC article.
Herein, we disclose a Ni-catalyzed 1,1-difunctionalization of unactivated terminal alkenes that enables the incorporation of two different heteroatom motifs across an olefin backbone, thus streamlining the access to alpha-aminoboronic acid derivatives from simple precursor …
Herein, we disclose a Ni-catalyzed 1,1-difunctionalization of unactivated terminal alkenes that enables the incorporation of two diff …
Catalytic Cleavage of Unactivated C(aryl)-P Bonds by Chromium.
Tang J, Ling L, Yuan S, Luo M, Zeng X. Tang J, et al. Org Lett. 2022 Mar 4;24(8):1581-1586. doi: 10.1021/acs.orglett.1c04325. Epub 2022 Feb 24. Org Lett. 2022. PMID: 35200020
We describe here the coupling to transform aryl phosphine derivatives by the cleavage of unactivated C(aryl)-P bonds with chromium catalysis, allowing us to achieve the reaction with alkyl bromides and arylmagnesium reagents under mild conditions. Mechanistic studies indic …
We describe here the coupling to transform aryl phosphine derivatives by the cleavage of unactivated C(aryl)-P bonds with chromium ca …
Unactivated Alkyl Chloride Reactivity in Excited-State Palladium Catalysis.
Muralirajan K, Kancherla R, Gimnkhan A, Rueping M. Muralirajan K, et al. Org Lett. 2021 Sep 3;23(17):6905-6910. doi: 10.1021/acs.orglett.1c02467. Epub 2021 Aug 25. Org Lett. 2021. PMID: 34432470
Herein, we demonstrate the excited-state palladium-catalyzed synthesis of oxindoles and isoquinolinediones via alkylation/annulation reaction by overcoming inherent limitations associated with unactivated C(sp(3))-Cl bond activation at room temperature....
Herein, we demonstrate the excited-state palladium-catalyzed synthesis of oxindoles and isoquinolinediones via alkylation/annulation reactio …
Undirected biocatalytic amination of unactivated C(sp (3))-H bonds.
Fu W, Yang Y. Fu W, et al. Chem Catal. 2022 Dec;2(12):3287-3289. doi: 10.1016/j.checat.2022.11.013. Epub 2022 Dec 15. Chem Catal. 2022. PMID: 36873821 Free PMC article.
In a recent JACS paper, Arnold and co-workers engineered P450 nitrene transferases to aminate unactivated C(sp (3))-H bonds with excellent site- and stereoselectivities....
In a recent JACS paper, Arnold and co-workers engineered P450 nitrene transferases to aminate unactivated C(sp (3))-H bonds with exce …
Manganese-Catalyzed Hydroarylation of Unactivated Alkenes.
Liu T, Yang Y, Wang C. Liu T, et al. Angew Chem Int Ed Engl. 2020 Aug 17;59(34):14256-14260. doi: 10.1002/anie.202003830. Epub 2020 Jul 6. Angew Chem Int Ed Engl. 2020. PMID: 32438503
Transition-metal-catalyzed hydroarylation of unactivated alkenes with strategic use of remote coordinating functional groups has received significant attention recently to address the issues of both low reactivity and poor selectivity. The bidentate 8-aminoquinoline amide …
Transition-metal-catalyzed hydroarylation of unactivated alkenes with strategic use of remote coordinating functional groups has rece …
Electroreductive Dicarboxylation of Unactivated Skipped Dienes with CO(2).
Zhang W, Liao LL, Li L, Liu Y, Dai LF, Sun GQ, Ran CK, Ye JH, Lan Y, Yu DG. Zhang W, et al. Angew Chem Int Ed Engl. 2023 Jun 5;62(23):e202301892. doi: 10.1002/anie.202301892. Epub 2023 May 3. Angew Chem Int Ed Engl. 2023. PMID: 37010979
Although dicarboxylation of activated alkenes, especially 1,3-dienes, has been widely investigated, the challenging dicarboxylation of unactivated 1,n-dienes (n>3) with CO(2) remains unexplored. Herein, we report the first dicarboxylation of unactivated skipped d …
Although dicarboxylation of activated alkenes, especially 1,3-dienes, has been widely investigated, the challenging dicarboxylation of un …
4,320 results